Correctly understand the inflammatory index procalcitonin – Sohu health

Correct understanding of inflammatory markers "procalcitonin" – Sohu health Hu Mei, Wang Ping, the PLA No.306 Hospital, Department of respiratory medicine brand quality management office of procalcitonin (PCT) as a marker has been widely used in clinic, both in the community hospital, ICU or respiratory infection, it is a kind of inflammation the index is used more and more widely. So what is a kind of material in the end? What is the role of it? The author introduces the basic knowledge. As the name suggests, procalcitonin is certainly associated with calcitonin. We know that calcitonin is a hormone that increases the risk of osteoporosis. Procalcitonin, which is the precursor of calcitonin, consists of 116 amino acids. In the C cells adjacent to the thyroid gland, the calcitonin gene related peptide -1 (CALC-1) was used as the template to form the transcription and translation, and it was quickly broken down into three parts: calcitonin, calcitonin, N terminal fragment. So the health of the human body, only a small part of the procalcitonin into the peripheral circulation, usually less than 0.05 ng L. But the drop comes not procalcitonin is single, which is mainly composed of thyroid parafollicular cells to secrete C, can also be secreted by neuroendocrine cells in the lungs, the distribution of the intestine, like small cell lung cancer cells can also secrete some. In the lung, intestinal inflammatory conditions or systemic inflammatory reaction conditions, resulting in a large number of PCT and PCT is not like degradation of thyroid parafollicular C cells as a function of these organizations, so PCT in the peripheral circulation under the condition of inflammation will rise. Usually the inflammatory tissue to produce PCT in 2 ways, one is produced by endotoxin or lipopolysaccharide stimulation, called the direct method; another is inflammatory mediators by bacteria stimulate immune cells to release tumor necrosis factor A or interleukin 1, 6, 8 as feedback signal molecules to stimulate tissue PCT for indirect way. After the stimulation of immune cells to produce inflammatory mediators are generally gamma interferon, can promote the attenuation of PCT, so the virus infection decreased PCT. So does the rise in procalcitonin mean bacterial infection? The answer was No. As clinicians, especially infectious diseases physicians, need to correctly understand the significance of PCT. The body’s immune response to inflammation is the core of the immune response. Lipopolysaccharide pathogen surface (LPS) with highly conserved molecular fragments called pathogen associated molecular module (PAMPs), immune cells have for this module the module identification ability of receptors called module recognition receptors (PRRs). When pathogens invade the body, the immune cells start immediately with the module through pathogen recognition receptors and pathogen associated molecular module, and the release of tumor necrosis factor (TNF-a) and interleukin 1 (IL-1), interleukin 6 (IL-6), interleukin 8 (IL-8) and other signal molecules caused by systemic inflammatory response and thyroid stimulating parafollicular C cells or lung tissue and intestinal neuroendocrine cells release PCT and PCT in the blood resulting in the inflammation of 2~4 hours.相关的主题文章: